Overall Summary on Clinical Efficacy With Ribomunyl

Overall Summary and Evaluation

Bosentan is a competitive inhibitor of endothelin receptors. In vitro, bosentan potently inhibits binding of endothelin-1 to human ET-A and ET-B receptors. Potency on ET-A receptors was only slightly greater than potency on ET-B receptors. Functionally, bosentan inhibits contractile effects of endothelin-1 in rat aorta and human blood internal mammary artery and vein. Oral administration of bos...

Summary of evidence on comparative efficacy

Summary of evidence on comparative efficacy

Summary of evidence on comparative efficacy

Summary of evidence on comparative efficacy